Ulcero-Protective Potential of Ethyl Acetate Fractions of Persea americana Seed and Bryophyllum pinnatum Leaf Binary Combinations in Indomethacin Induced Gastric Ulcer

Aims: This study was aimed at investigating the protective potential of ethyl acetate fractions Persea americana (PA) seed and Bryophyllum pinnatum (BP) leaf binary combinations against indomethacin-induced gastric ulcers.
 Methodology: Fifty (50) male Wistar rats were used in this study; they assigned into 10 groups five animals each respective received a standard rat diet drinking water ad libitum. The group 1 (normal control (NC)), 2 (ulcer (UC)), 3 (Omeprazole, 20mgkg-1 (OMEP)), 4 5 (BP). Groups receiving 6 (PA + BP, 1:1), 7 1:2), 8 1:3), 9 2:1), 3:1) pre-treated with 400 mgKg-1 body weight/day fraction or mixture by intubation for 21 days. On 22nd day after overnight fasting, ulcer induced indomethacin (30mg/kg weight) single dose. Ulcer markers histopathology stomach tissues measured using methods.
 Results: present revealed that plants PA seeds BP showed potent tissue effects. Analysis changes indicated significant (P<0.05) reduction index, acid output, mucus content pepsin activity ulcerated pretreated fractions. effect significantly (p<0.05) higher than plant order OMEP > PA+BP (3:1) (2:1) (1:1), (1:2) (1:3) BP. observed ulcero-protective P. B. may be attributed to synergy phytochemicals contained fractions.
 Conclusion: These findings suggest combination favorably protect mucosal oxidative damage, reducing activity. exhibited dose-dependent inhibition formation model.